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KMID : 0377519980230010045
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Chung-Ang Journal of Medicine
1998 Volume.23 No. 1 p.45 ~ p.50
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Mangganese-superroxide dismutase activity in type II diabetes mellitus patients with retinopathy before and after treatment with vitamin E
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Bae Hyun-Cheol
Choi Seong-Nam
Kong Byoung-Ho
Oh Yeon-Sahng
Shinn Soon-Hyun
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Abstract
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There are some evidences that oxidative stresses have some roles in initiation and progression of the diabetic complications. Superoxide dismutase (SOD) is an essential enzyme for the dismutation of superoxide(:O2＾-) radicals, and the activity is changed in some pathologic conditions such as diabetes. The aim of this study was to evaluate the association of Mn-SOD activity and severity of diabetic retinopathy and to compare between before and aftertreatment with vitamin E. The Mn-SOD activities were measured in 75 patients with NIDDM(41 noretinopathy, 21 nonproliferative retinopathy, 13 proliferative retinopathy) by spectrophotometry. The Mn-SOD activity(U/mg protein) was significantly elevated in diabetes after vitamin E treatment. The severity of diabetic retinopathy appeared not be statistically significant. In diabetic patients, there were no correlation between the Mn/SOD activity and the various clinical and biochemical parameters.
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KEYWORD
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Mn-SOD, diabetic retinopathy, vitimin E
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